Identification of human GnIH homologs, RFRP-1 and RFRP-3, and the cognate receptor, GPR147 in the human hypothalamic pituitary axis.

The existence of a hypothalamic gonadotropin-inhibiting system has been elusive.A neuropeptide named gonadotropin-inhibitory hormone (GnIH, SIKPSAYLPLRF-NH(2)) which directly inhibits gonadotropin synthesis and release from the pituitary was recently identified in quail hypothalamus.Here we identify GnIH homologs in the human hypothalamus and chara

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Altered Glycosylation in the Aging Heart

Cardiovascular disease is one of the leading causes of death in developed countries.Because the incidence increases exponentially in the aging population, aging is kids t-shirt a major risk factor for cardiovascular disease.Cardiac hypertrophy, fibrosis and inflammation are typical hallmarks of the aged heart.The molecular mechanisms, however, are

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